Tamassee is an unincorporated community and census-designated place (CDP) located in northwestern Oconee County, South Carolina, United States.

A large part of the community occupies the scenic Cheohee Valley, "a beautiful rolling meadow framed by mountains and a wide triangle of sky.

The area is noted for its extremely rich biological diversity; which is said to owe to unique soil characteristics and elevated annual precipitation levels.

[9] The Cherokee town of Tamassee was destroyed and abandoned on August 12, 1776 when Major Andrew Pickens of the South Carolina Militia fought in the famed "Ring Fight".

[10] Today, the Tamassee area maintains a rural and agricultural foundation, and provides a pleasant setting for day hikes, country drives and historical investigation.