Tando Muhammad Khan (Sindhi: ٽنڊو محمد خان; Urdu: ٹنڈو محمد خان) is a city and headquarter of the Tando Muhammad Khan District located in Sindh, Pakistan.

Traditional shawls called "Ajrak" is among the most famous Sindhi culture wearing is also produced in Tando Muhammad Khan.

Majority of population consists of Sindhi people, Urdu speaking (mohajir) are the largest minority in Tando Mohammad Khan city.

Others ethnic groups are Bagri, Bheels, Kolli, Meghwars, ranghar or rangar, mehwati, Punjabi, Pathans, and few others.

So, following are the languages spoken in TMK city: Bheeli, Gujarati, Kutchi, Memoni, Mehwati, Bagri, Punjabi, Pushto, Pothowari, Seraiki and Brohui.