Tanguy Nef started skiing when he was 6 years old on the slopes of the Valais central in French-speaking Switzerland, following in the footsteps of his family members.

In 2016, shortly after his first podiums in FIS slalom, he competed in his first European Cup events then took part in his first Junior World Championships.

He then moved to the United States to study computer science at Dartmouth College where he completed a bachelor's degree and was a member of the Beta Alpha Omega fraternity.

In 2017, he competed in the North American Cup (5 top10, including 3 top5) and participated in the FIS Alpine Junior World Ski Championships in Åre.

During the 2019-2020 season, he scored points at Levi and Zagreb once again before securing the top 10 twice in a World Cup race in January 2020, at Madonna di Campiglio and Wengen.