Wexler is known for exploring women's issues in her films and including complex female characters.

[6] She attended Yale University ('92) where she studied psychology[7] and was roommates with actress Bellamy Young.

[6] Wexler has directed five feature films: Finding North (1998), Relative Evil (2001), Hysteria (2011), Buffaloed (2019), and Jolt (2021).

[9][10][11] Wexler also directed portions of the following TV Series: The Girlfriend's Guide to Divorce (2017), The Arrangement (2018), and Partner Track (2022).

[1] Wexler is involved in producing the upcoming Amazon Prime Movie, Tough Love.

[citation needed] Wexler's 2011 feature film, Hysteria, starring Maggie Gyllenhaal and Hugh Dancy, is a satirical romcom about the man who created the vibrator (Joseph Mortimer Granville) and the experience of being a woman in Victorian England.

A few historians have asserted that the vibrator was used as a replacement for genital massages used to treat hysteria, however these claims are unsubstantiated.

[15] Wexler and Zimmerman married on May 19, 2004, in Massachusetts, the first U.S. state to issue marriage licenses to same-sex couples.

For example, Wexler has served on the board of directors for the Gay and Lesbian Alliance Against Defamation (GLAAD).