In 2024, he was named an All-Star and became the first American League pitcher to win the Cy Young Award and Triple Crown in a full season since 2011.

[11] On August 18, Skubal was recalled from the Tigers' satellite training facility in Toledo, and he made his MLB debut later that day.

In five innings pitched, Skubal allowed two earned runs and three hits while striking out two and walking none in the Tigers' 4–2 win.

[14] With the 2020 Detroit Tigers, Skubal appeared in 8 games, compiling a 1–4 record with 5.63 ERA and 37 strikeouts in 32 innings pitched.

[17] On July 3, Skubal recorded his 100th strikeout of the season, becoming the first Tiger rookie ever to strike out at least 100 batters before the All-Star break.

After posting a 7–8 record with a 3.52 ERA, 111 ERA+, 1.16 WHIP and 117 strikeouts in 117+2⁄3 innings, he was placed on the injured list on August 3 with fatigue in his pitching arm.

On August 17, the Tigers announced Skubal had undergone flexor tendon surgery, definitively ending his 2022 season and likely sidelining him for the beginning of 2023.

[20] On March 14, 2023, the Tigers moved Skubal to the 60-day injured list, stating that he wasn't expected back on the mound until summer.

[22] He was named American League Pitcher of the Month in September, finishing his final five starts with a 4–0 record and 0.90 ERA.

[23] In a May 5 game against the New York Yankees, Skubal became the first Tigers pitcher in over 100 years to strike out 12 or more batters without issuing a walk.

[33] On the strength of his Triple Crown campaign, he won the Cy Young Award unanimously, earning all 30 first-place votes.