The town emerged briefly in the 1880s as an economic rival of Dodge City, Kansas.

Located in Oldham County, northwest of Amarillo, Tascosa is now a ghost town.

In 1893, the bridge was washed out and the flood damaged homes and businesses, so people began to move away.

Tascosa was the setting for the showdown between Lin McAdams (Jimmy Stewart) and Dutch Henry Brown (Stephen McNally) in the 1950 American Western film, Winchester 73.

Stewart also played the sheriff of Tascosa, Guthrie McCabe, in the 1961 production Two Rode Together.