Tatyana Akbarovna Karimova (Russian: Татьяна Акбаровна Каримова) is an Uzbek economist who held the position of First Lady of Uzbekistan from 1991 until the death of her husband in September 2016.

Karimova, together with Rustam Inoyatov, the head of the National Security Service, was expected to play a key role in choosing Karimov's successor.

[1] Born in the harsh years following World War II into a military family, Karimova, who is of Russian and Tajik origin, moved with her parents to the Fergana Region in 1952.

[3] Tatyana Karimova was working as a researcher at the Institute of Economics at the Academy of Sciences of Uzbekistan at the time of her wedding to Karimov.

[6] Gulnara Karimova accused her mother of trying to "destroy" for attempting to prevent the arrest of her cousin, Akbarali Abdullayev.