The Taurus TX22 is a semi-automatic pistol chambered for .22 Long Rifle (5.59 mm Caliber) rimfire ammunition.

An adapter collar is included to allow the use of a suppressor with an external thread of 1/2-28 inches.

The trigger is single action only, and the frame features a Picatinny rail.

Numerous variants are available with compact frames, varying slide and barrel configurations among other differences.

In 2019, the TX22 was awarded the title of "Handgun of the Year" by Guns and Ammo magazine.