He played in Major League Baseball (MLB) from 2008 to 2015 for the Texas Rangers, Baltimore Orioles, New York Mets, and Chicago Cubs.

Most notably, Teagarden played on the Longhorns' 2005 NCAA Championship team, which won the College World Series.

[3] Sent to the Double-A Frisco RoughRiders early in the 2010 season, Teagarden was called back up to the Majors in July 2010 due to the injuries of catcher Matt Treanor.

Teagarden was cleared to begin baseball activities on June 1, 2012, and began his minor league rehab games with the Double-A Bowie Baysox on July 6.

On the same day, he was activated by the Orioles off the disabled list on July 14,[5] he hit a two-run, two-out homer off Joaquín Benoit to end a 13-inning 8–6 victory over the Detroit Tigers at Camden Yards.

[12] On July 4, the Cubs needed catching depth and called up Teagarden to backup starter Miguel Montero behind the plate.

[14] On December 26, 2015, Teagarden was named in an Al Jazeera report linking him to performance-enhancing drugs (PED) usage.