He participated in the 2008 Summer Olympics as a member of the United States national baseball team and won the World Series with the Cubs in 2016.

[2][3] As a minor leaguer during the 2008 season, Fowler was selected to represent the United States in the 2008 Summer Olympics in Beijing, China.

He made his debut that same day in a 6–5 extra-inning home win over the San Francisco Giants, coming in as a pinch runner in the bottom of the 10th inning; he was subsequently picked off at first base.

[7] On September 10, 2008, Fowler recorded his first hit, an infield single, off of Will Ohman in the top of the seventh inning of a 9–5 road loss against the Atlanta Braves.

[8] On April 8, 2009, Fowler hit his first career home run off Doug Davis of the Arizona Diamondbacks, as part of a 9–2 road win.

[9] On April 27, 2009, Fowler tied a modern-day rookie record when he stole five bases against the San Diego Padres in a 12–7 victory.

[citation needed] On December 3, 2013, Fowler was traded, along with a player to be named later to the Houston Astros for outfielder Brandon Barnes and pitcher Jordan Lyles.

[18] The Orioles claimed that Fowler's insistence on an opt-out clause after one year was the holdup on the deal and that they were blindsided when he signed with the Cubs.

Fowler on the other hand insisted he never had agreed to a deal with the Orioles and he and his agent blamed the team and the media for leaking incorrect information.

[19] Fowler earned his first career MLB ejection for arguing a strike three call by umpire Vic Carapazza on May 5, 2016.

[21] On October 25, 2016, Dexter Fowler along with teammates Jason Heyward, Addison Russell, and Carl Edwards Jr. became the first African-Americans to play for the Cubs in a World Series game.

[28] He hit his first home run and RBI as a Cardinal against Pittsburgh Pirates pitcher Gerrit Cole on April 19, 2017.

[31] On August 21, 2018, Fowler was placed on the 60-day disabled list,[32] ending a disappointing 2018 season in which he slashed .180/.278/.298 with eight home runs and 31 RBIs in 90 games.

[35] In an April 9 game against the Toronto Blue Jays, Fowler was carted off of the field after suffering an apparent knee injury after awkwardly sliding into second base.