It was designed by Giuseppe Pestagalli to a commission from Count Francesco Dal Verme, and was used primarily for plays and opera performances throughout the 19th and early 20th centuries.
Today, the theatre is no longer used for opera, but is a venue for concerts, plays and dance performances, as well as exhibitions and conferences.
It opened on 14 September 1872 with a production of Meyerbeer's Les Huguenots and soon established itself as one of Italy's most important opera houses.
It was then severely damaged by American aerial bombardment during World War II, after which its magnificent central cupola, which had survived the bombing, was stripped of all its metal parts by the occupying German army.
In 1991, the theatre's interior underwent a major restructuring and renovation project which was completed in 1998.