The kits are delivered to nuclear pharmacies as lyophilized powders of non-radioactive ingredients sealed under nitrogen.

A nuclear pharmacist adds anywhere from 50 - 100 mCi of Na[99mTcO4] to the reaction vial to make the final product, in the pH range of 3.8 to 8.0.

After being allowed to react at room temperature for 15 minutes to ensure maximum labeling of the human albumin with 99mTc, the kit can then be diluted with sterile normal saline as needed.

[medical citation needed] Because of gravity effects, people administered 99mTc MAA should be in the supine position to ensure as even a distribution of particles throughout the lungs as possible.

[medical citation needed] The total percentage of particles trapped in the lungs can be determined through a whole body scan after the administration of 99mTc MAA through the equation:[medical citation needed] The technetium tc 99m aggregated albumin kit was approved for use in the United States in December 1987.