Though the group's lineup has fluctuated throughout their career, singer/guitarist Ted Leo has remained the band's main songwriter, creative force, and only constant member.

[2] After the breakup, Ted spent time producing and working on albums for the Spinanes, the Secret Stars, and Jejune.

He also fronted the Sin Eaters, a short-lived band featuring members of the Van Pelt and Native Nod.

[4] In 2000, Leo expanded the project to a full band including James Canty on guitar, Jodi Buonanno on bass and Amy Farina on drums.

The EP moved away from many of the experimental elements of tej leo by relying on more traditional rock structures and instrumentation, though it still explored some non-traditional characteristics.

During the supporting tours for the album, bassist Dave Lerner, drummer Chris Wilson, and keyboardist Dorien Garry became permanent members.

A video documentary of the band performing at the 2003 Siren Music Festival in Coney Island, Dirty Old Town, was released in early 2004 by Plexifilm.

[6] Prior to the recording of 2004's Shake the Sheets, Garry and Canty left the band, reducing the group to a trio.

Bassist Lerner played his last show with the band at McCarren Park Pool in Brooklyn, NY on August 12, 2007.

On February 13, 2024, Leo announced the Pharmacists would be going on a US tour in celebration of the 20th anniversary of Shake The Sheets with opening support from Ekko Astral and Diners.