During his professional football career, he played for the Columbus Panhandles, Massillon Tigers, Akron Indians, Canton Bulldogs and Shelby Blues.
In 1906, he reputedly ended the career of Willie Heston, a former Michigan All-American, with a hard tackle in a Massillon Tigers-Canton Bulldogs game.
In 1908, Ted reputedly stayed for a game with two broken bones protruding from an arm, just because he thought that his brothers needed him.
He was also considered a football genius and is credited with originating several plays including the triple pass, the criss-cross and the short kickoff.
In 2015, the Professional Football Researchers Association named Nesser to the PRFA Hall of Very Good Class of 2015.