Frederick W. Nesser (September 10, 1897 – July 2, 1967) was a professional American football player in the "Ohio League" and the early National Football League (NFL) for the Columbus Panhandles.
He was the tallest and biggest of the football-playing brothers at six feet five inches and 250 pounds.
He played mostly tackle or end, but sometimes he lined up in the backfield, to provide blocking.
Fred also was a professional boxer and a legitimate contender for the heavyweight title, held by Jess Willard.
Around 1987 Fred's daughter, Vera, tried to get the city of Columbus to name a street for the Nesser Brothers.