The Tefé River (Teffé River in early accounts; Portuguese: Rio Tefé) is a tributary of the Amazon River (Solimões section) in Amazonas state in north-western Brazil.

The Tefé River flows through the Juruá-Purus moist forests ecoregion.

[3] It forms the eastern boundary of the Tefé National Forest, created in 1989.

The city of Tefé is located on the banks of the lake.

This article related to a river in the Brazilian state of Amazonas is a stub.