It is found in the Mojave Desert of the North American southwest, specifically southern California, southern Nevada, southwestern Utah, and western Arizona.

Most Tegeticula species, including T. antithetica, are monophagous, and the adult moths only live for a few days, so they must access the plant during the short flowering period.

This indicates that moth populations would have to be locally adapted for the flowering periods their specific hosts.

[2] Godsoe, et al. (2008) presented convincing evidence for coevolution of Tegeticula synthetica and Tegeticula antithetica by showing the exclusive relationship between the two species and their respective populations of Yucca brevifolia, with antithetica being limited to Y. brevifolia var.

Perhaps most importantly, Godsoe et al. showed that only the reproductive features of the moths and plants have been evolving—ovipositor length and floral characters, respectively—and not body size or vegetative features, respectively.