The earliest known mention of the Tekezé is in an inscription from Aksum of king Ezana of Axum, where he boasts of a victory in a battle on its lower banks, near "the ford of Kemalke".

Augustus B. Wylde records a related tradition that near the source of the Tekezé, at the location of Eyela Kudus Michael church, is the true resting-place of the Ark of the Covenant.

[7] Between February and March 1936, during the Second Italo-Abyssinian War, thousands of Ethiopian troops were killed when the Italian Royal Air Force (Regia Aeronautica) attacked them with bombs and mustard gas as they retreated across the Tekezé.

"[9] The Ethiopian government announced in July 2002 that they had formed a partnership with the China National Water Resources and Hydropower Engineering Corporation to construct a hydroelectric dam on the Tekezé, which would generate 300 megawatts of electricity.

[10] Oweys Ibrahim, the project coordinator, announced on 12 December 2007 that construction was 82% complete, and included a 105-kilometer power line to Mekele.