The Anseba River (Tigrinya: ሩባ ዓንሰባ, Tigre: عنسبا) is a tributary of the Barka River in Eritrea with a length of 346 kilometres.

It rises in the Eritrean Highlands outside Asmara and flows in a northwestern direction through Keren.

It merges with the Barka River near the border with Sudan.

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