The area around Xochicalco (In the place of the House of Flowers) was settled in about 200 BCE, although the city reached its apex between AD 650 and 900.

[7] Xochicalco was mentioned by Fray Bernardino de Sahagún in the 16th century, and it may have been settled by refugees from Teotihuacan.

According to petrographs found in the Templo de las Serpientes Emplumadas, (Temple of the Feathered Serpents) Xochicalco hosted a meeting with representatives from the Maya area, the Gulf Coast, and Oaxaca to adjust the calendar during a solar eclipse while Xochicalco was at its splendor.

At the time of the formation of the Triple Alliance (1428), the only communities in the modern-day municipality of Temixco were Acatlipa and Cuentepec.

[9] After the Spanish conquest of 1521, Hernán Cortés was granted the title Marqués del Valle de Oaxaca including almost all of modern Morelos.

[9] Martín Cortés, 2nd Marquis of the Valley of Oaxaca granted lands to religious orders and wealthy Spanish were able to establish the first sugar-cane plantations or haciendas.

1617, Don Francisco Barbero of Copaltepeque established the Hacienda of Temixco on 1,755 hectares of land.

[9] The owner of the hacienda, Miguel de Zia, seized land in Xochitepec and Alpuyeca in 1715 with the support of Fray Simón Roa of the Holy Inquisition.

Indigenous of Alpuyeca rose against the hacienda in 1747, only to be arrested by Fray Miguel de Nava of Cuernavaca.

[9] In 1808, don Gabriel Joaquín de Yermo celebrated his wife's birthday by freeing 200 slaves from his hacienda in Temixco.

When the Mexican War of Independence broke out in 1810, Gabriel Joaquín de Yermo converted the hacienda into a supply center for the Royalists.

[9] In the 1940s the Comité Japonés de Ayuda Mutua (CJAM; "Japanese Committee of Mutual Aid"), a Japanese-Mexican organization based in Mexico City, obtained a hacienda on 200 hectares (490 acres) of land in Temixco from Alejandro Lacy so it could house newly-arriving Japanese coming from other parts of Mexico.

[13] Eventually, Mexican parents began asking for their children to attend the Temixco Japanese school.

Construction on a bridge to connect Mexican Federal Highway 95D in Apatlaco, Ayala and the Cuernavaca Airport in Temixco was begun in 2012 and the project ended in November 2012.

Camacho García had a tumultuous rule, becoming ill and dying six months later from cardiorespiratory arrest in July 2017.

[19] In 2020, Gambia Lozano, who worked for the presidency of Enrique Peña Nieto, and four members of his family were murdered by the Colombian drug cartel El Señorón in May 2020.

There are 22,089 homes; 1,413 have a dirt floor; 2,242 consist of a single room; 20,744 have water and sewage; 21,011 have electricity; 2,560 have a computer, and 20,338 have television.

[36] Acatlipa (from Nahuatl, meaning Sanctuary of the god of wind) is south of the city of Temixco bordering Xochitepec.

Its three most important festivals are April 2 (the town anniversary), November 30 (San Andrés Apostol),[37] and January 20 (Immaculate Conception).

The major agricultural communities are Temixco, Acatlipa, Cuentepec, Tetlama, and Pueblo Viejo.

[28] Ceramics are important in Colonia Tres de Mayo, and there are a number of small-scale clothing factories.

[41] Parque Acuático Ojo de Agua in Acatlipa has an Olympic pool, water slide, picnic area, hanging bridge, and mini zoo.

[42] There are a variety of stores with clothing, shoes, construction materials, food and groceries, and hardware in the larger communities.

Mexican Federal Highway 95D, also called Autopista del Sol crosses the municipality from north to south (Mexico City — Cuernavaca — Xochitepec — Acapulco) with several exits in Temixco.

There are local highways connecting other communities, the Xochicalco archaeological site, and the Cuernavaca Airport.

The airport opened on April 15, 1988; due to its short runway of only 2,772 metres (9,094 ft), it has offered on-again / off-again service since then.