[3][4][5] As a young man, Jables (JB) runs away from his strict, religious family and oppressive Midwestern town for Hollywood after being graced by the word of Dio on a quest to form the world's "most awesome" rock band.

There, he meets acoustic guitarist Kage (KG), who is performing on the street, and begins worshiping him as a rock god.

KG takes pity on JB and agrees to teach him, letting him sleep on the couch in his small apartment.

A nearby blacksmith heard the commotion and distracted the demon by tossing a horseshoe at it, chipping its tooth in the process.

To repay the blacksmith, who desired the heart of a fair maiden, the wizard fashioned the tooth into a pick that would give its holder unnatural prowess with stringed instruments.

The owner is revealed to be Satan in human form, who places the Pick of Destiny back on his broken tooth.

To save their lives, Tenacious D challenge Satan to a rock-off, which under the terms of the "demon code" he cannot decline.

After the duel, Satan deems his rock better and attempts to shoot KG with a bolt of lightning from his fingertips, but JB jumps in the way to save him, and the bolt bounces off the "JB KG" drawn logo on the base of his guitar, blowing off a piece of Satan's horn.

[13] Filming had been expected to take place by the end of 2003;[14] however, it was delayed by almost a year due to Black being cast in Peter Jackson's big budget remake of King Kong.

[16] Principal photography for Tenacious D in The Pick of Destiny commenced in the spring of 2005, with the production finishing later that summer.

[18] The film held two re-shoots in the summer of 2006 and according to Lynch, every crew member from the principal photography came back because they "had such a fun time working on set".

[1] The soundtrack, the band's second studio album, includes vocals by Ronnie James Dio and Meat Loaf.

[24] Tenacious D in The Pick of Destiny had its British premiere on November 1, 2006, at the Vue West End cinema in London, England.

Many of the actors who had cameos in the film were in attendance; including Ronnie James Dio, Dave Grohl, and Ben Stiller.

Tenacious D in The Pick of Destiny performed poorly at the box office, only grossing a total of $8.2 million in the United States.

Wal-Mart customers received a copy of the CD More Rocktastic Music from the Film bundled with the DVD, featuring excerpts of the score by Andrew Gross and John King, as well as songs from Gass' Trainwreck.

In 2016, the band marked ten years of the film's release by using The Pick of Destiny as their backdrop at various European festival appearances.