SR 152 begins in Crockett County in Cairo at an interchange with US 412/SR 20, where the road continues west 1.75 miles as Reynolds Road to SR 189.

Some maps erroneously label this as Nichols Road, even though this is incorrect.

It goes east to have an intersection with SR 188 before leaving the community and continuing through rural areas, where it has an intersection with SR 54, before crossing into Gibson County.

SR 152 passes through downtown along W Church Avenue, then Main Street, and finally E Foster Avenue, before leaving Medina and continuing east through farmland to cross into Madison County.

[3][4] It turns southeast to cross the Middle Fork of the Forked Deer River, for a second time, to pass through Spring Creek, where it has a short 70 feet concurrency with US 70/SR 1, before turning completely south and having an interchange with I-40 (Exit 93).