It crosses the Cumberland River twice, once near Madison, and again on the west side of Nashville, near the Riverbend Maximum Security Institution and John C. Tune Airport.

The parkway then crosses the Cumberland River on the Andrew B. Gibson Bridge, and has an interchange with County Hospital Road near the University School of Nashville.

[3] At this point, Briley Parkway widens to eight lanes, and begins a brief concurrency with US 31E, which splits off northbound as Gallatin Pike at an interchange 0.6 miles (0.97 km) later.

Here the parkway reaches an interchange with McGavock Pike, which is a connector road to the Gaylord Opryland Resort & Convention Center, Music Valley, and the site of the Grand Ole Opry.

Continuing as a limited access highway, Briley Parkway has intersections with three major thoroughfares before reaching a trumpet interchange with Airways Boulevard, an exit to the former site of Nashville's Berry Field airport.

The route continues for another mile, next to an aircraft manufacturing site adjacent to the airport, before reaching an interchange with US 41/70S (Murfreesboro Pike).

[3] The segment of SR 155 designated as White Bridge Road begins at the interchange with I-40 in west Nashville, where the route continues north as controlled-access Briley Parkway.

Beyond this point, the route immediately has an intersection with US 70, and runs directly north-south before curving to the southeast over 1 mile (1.6 km) later near Nashville State Community College.

About 2⁄3 mile (1.1 km) later the road curves to the southeast, and begins running east-west nearly perfectly straight before reaching an intersection with US 431 (Hillsboro Pike).

Continuing east, SR 155 passes through a short and divided tunnel beneath the north end of a railyard and about 1.25 miles (2.01 km) later intersects with US 31A/41A (Nolensville Pike).

[4] The 2.2 miles (3.5 km) segment of Briley Parkway between the intersection with Thompson Lane and Vultee Boulevard just north of US 41/70S opened to traffic in on October 29, 1965.

[4] On December 21, 1989, the section between Centennial Boulevard and SR 12 (Ashland City Highway), including the bridge over the Cumberland River, opened.

[15] The final phase involved widening the parkway between I-40 and Elm Hill Pike and reconstructing the interchange with I-40, which was completed in December 2006.