SR 211 begins as an unsigned route concurrent with US 51 Business inside the city limits of Dyersburg.

The route in this area is mostly a two-lane facility with a few four-lane and five-lane sections with a maximum speed limit of 50 miles per hour (80 km/h).

This route passes through downtown Newbern and intersects SR 77 before continuing north toward Trimble.

Tennessee Department of Transportation ended state maintenance on the section of this highway between Trimble and Obion due to the deteriorated nature of the bridges along this section of roadway and the derelict Adkison Memorial Bridge over the Obion River that has been closed for a number of years.

North of Troy the old two-lane alignment of US 51 resumes and is currently signed as SR 184 and runs to Union City.