State Route 224 (SR 224) is a 26.6 miles (42.8 km) north-south state highway that is located almost entirely in McNairy County, Tennessee, connecting Michie with Enville via Stantonville and Adamsville.

SR 224 the leaves Stantonville along Gilchrist Stantonville Road to pass through farmland before making a sharp left turn at an intersection with Gilchrist Road to come to an intersection with US 64/SR 15, which it becomes concurrent with.

They head northeast to the extreme western edge of the Adamsville city limits, where SR 224 splits off along Leapwood Enville Road to go northwest, then north through farmland.

The highway continues to wind its way north through a mix of farmland and wooded areas to enter Enville just shortly before crossing into Chester County.

Excluding the concurrency with US 64/SR 15, the entire route of SR 224 is a two-lane highway.