State Route 225 (SR 225) is a 17.1-mile-long (27.5 km) north–south secondary state highway located in West Tennessee.

It connects Hornsby with Henderson.

It winds its way north to enter Chester County and pass through wooded and hilly terrain, along with the communities of Woodville, Masseyville, Hickory Corners, and Montezuma.

The highway then comes to an end near Henderson at an intersection with SR 100.

The entire route of SR 225 is a rural two-lane highway.