State Route 359 (SR 359) is a 4.9-mile-long (7.9 km) north-south state highway located entirely in Carter County, Tennessee.

[2] SR 359 begins at an interchange with I-26/US 19W/US 23 exit 27.

From this interchange, SR 359 travels eastward to South Roan Street; it then turns north onto, and merges with, South Roan Street for 0.2 miles (0.32 km) to an intersection where South Roan Street continues north and SR 359 turns northeast and continues a north-northeast track to Milligan Highway.

SR 359 turns east on to Milligan Highway and continues a northeasterly track until it ends at an intersection with US 321/SR 67.

The entire route is in Carter County.