State Route 365 (SR 365) is a secondary north–south state highway located in Henderson, Chester County, Tennessee.

It then continues east through downtown Henderson as Main Street for approximately 0.8 miles (1.3 km) and turns in front of Freed-Hardeman University[2] onto White Avenue and continues for approximately 2.5 miles (4.0 km) ending between mile markers 7 and 8 of US 45.

Main Street at one time was part of SR 100 until the Noah Weaver Bypass was constructed which bypassed the downtown area.

White Avenue was also once known as US 45 Business.

[3] The entire route is in Henderson, Chester County.