It connects the towns of Rutherford and Greenfield and provides access to Big Cypress Tree State Park.

SR 445 begins in Gibson County at an intersection with SR 105, just across the Rutherford Fork of the Obion River from the town of Rutherford.

The highway then crosses a bridge over the South Fork of the Obion River shortly before crossing into Weakley County.

SR 445 then enters Greenfield, where it comes to an end at an intersection with US 45E/SR 43 at the northern edge of town.

The entire route of SR 445 is a two-lane highway.