SR 76 is unique in that it actually changes its cardinal directions (from North-South to East-West) in Clarksville at the junction with US 41A and US 41A Bypass.

They then intersect SR 425 before leaving Milan and widening to a 4-lane divided highway for a short distance before narrowing back down to a 2-lane to cross into Carroll County.

They then pass through countryside and intersect SR 140 south of Buchanan before entering Paris Landing State Park and junctioning with SR 119 before crossing the Ned McWherter Memorial Bridge over Kentucky Lake/Tennessee River into Stewart County.

US 79/SR 76 then enter the Land Between the Lakes National Recreation Area and intersect with SR 232 and several park access roads, including the SR 461 (The Trace), before narrowing to 2-lanes to enter Dover and leaving the park.

In downtown they intersect with SR 49 before leaving Dover by crossing the Cumberland River as a 2-lane highway.

For four miles (6 km) past this junction, SR 76 widens to a four lane divided highway.

It then passes through Port Royal and junctions with SR 238 before crossing Sulphur Fork Creek into Robertson County.

US 41/SR 11/SR 76 then leave Adams and goes south east and passes through Cedar Hill before entering Springfield and coming to an intersection with US 431/SR 65.

SR 76 then becomes concurrent with US 31W/SR 41, turning north, for approximately two-tenths of a mile before branching off to the east again.

At this point, SR 76 crosses in Sumner County and passes through some neighborhoods before leaving White House and going northeast through farmland once more.