The 44.78 miles (72.07 km) route traverses Lauderdale and Crockett Counties.

SR 88 begins at a dead end overlooking the Mississippi River within Chickasaw National Wildlife Refuge.

SR 88 has junctions with State Routes 210 and 209 before turning eastward once again at Gates.

[2][3] SR 88 then traverses the town of Maury City and Alamo.

[2][3] At one time, SR 88 once connected with Arkansas Highway 18 into Mississippi County, Arkansas via a ferry on the Mississippi River.