The former originates north of Planchón volcano at Lagunas de Teno.

At the locality of Los Queñes, the Teno is joined by the Claro River, which is fed by glaciers of Planchón-Peteroa complex.

Shortly after being crossed by the Pan-American Highway and by Chile's main railroad, the Teno River turns its course southwestward until it meets the Lontué River, about 10 kilometers west of Curicó near the locality of Sagrada Familia, forming the Mataquito River.

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