From the Maya words "Tana" or house and "tsiic" weaving or counting threads.

Which leaves us with "casa de los hilanderos " or "House of Weavers or thread counters".

in the Preclassic Maya Period (according to Magnolia Paz Nexo in her book Tenosique Prehispánico y Colonial edited by the Government of Tabasco).

Vice President and national hero of the Revolution, José María Pino Suárez was born in Tenosique in 1869, and the town now bears his name.

Tenosique is also the site of a railway station on the Tren Maya.