In 1994 he started working as an actor for Scherzi a parte and then as host of Seven Show on broadcaster Europa 7.

In 1999 he appeared in Le Iene (The Hyenas), a television program broadcast on the Italian channel Italia 1.

He then presented Mio fratello è Pakistano (2005), Distraction (2006 and 2007), Cultura Moderna (2006 and 2007, together with the Brazilian model Juliana Moreira), Primo e Ultimo (2008), Scherzi a parte (2009, with Claudio Amendola and Belén Rodríguez) and Sarabanda (2009, with Belen Rodriguez).

In autumn 2012,[1] Mammucari hosted Lo show dei record, broadcast on Canale 5.

[2] As an actor, he starred in the cinema with the film Witches to the North (2001) by Giovanni Veronesi and in the television series Piper (2009), based on the 2007 TV movie by Carlo Vanzina of the same title.