Between 1571 and 1588 the Tercio of Sicily fought in Flanders against Prince William the Silent, in Tunis against the Ottomans, and in 1580 in the War of the Portuguese Succession.
In the latter part of the century, the tercio found itself in France again and later was assigned the quelling of the rebellion of the Kingdom of Sardinia in 1699 and Messina in 1673.
During the 18th century, the tercio participated in Italian campaigns as well as those in Portugal, Spanish America, and north Africa.
During the Peninsular War the tercio participated in the battles of Bailén, Tudela, Talavera, Ocaña, Chiclana, and Sagunto.
Just before the Spanish Civil War, it changed its name multiple times settling on "Mountain Battalion Sicily No.
In recent years, its units have participated in international missions in Bosnia Herzegovina, Lebanon, Kosovo, Iraq, and Afghanistan.