She was the elder daughter of Court and Grand Marshal, Prince Józef Karol Lubomirski and his wife Princess Teofilia Ludwika Zasławska, niece of Polish King Jan III Sobieski.

She married Charles III Philip (Wittelsbach), heir to the Electorate of the Palatinate, on 15 December 1701 in Kraków.

He had one surviving child from his previous marriage, an eight-year-old daughter, Elisabeth Auguste Sophie.

Theophila Elisabeth Franziska Felicitas was born 13 November 1703 and died on 31 January 1705, when she was one year old.

Anna Elisabeth Theophila was born Four years later 09 June 1709, and died aged two, on 10 February 1712.