Termoli railway station is situated at Piazza Giuseppe Garibaldi, close to the city centre.

[1] Earlier, on 9 November 1863, King Victor Emmanuel II had officially opened the section between Pescara and Foggia, by setting forth aboard a special train, on track that had been hurriedly completed especially for the event.

The configuration of the original passenger building is fairly typical for Italian railway stations.

Each platform is accessible from the others by an underpass, which also functions as a pedestrian link between two parts of the city: Viale Trieste and Piazza Garibaldi (or station square).

In October 2010, work was completed on the modernization of the facade of the passenger building overlooking Piazza Garibaldi and its waiting rooms and interior passages.

The main destinations for trains leaving Termoli are Foggia, Campobasso, Pescara and, recently, Teramo.