The last Milwaukee Road service was a short line route to Bedford, Indiana to the southeast.

[3][4] Barbara Carney, a railroad museum administrator, said that Buffalo Bill, Jack Benny, and presidents Benjamin Harrison, William McKinley, Theodore Roosevelt, William Howard Taft, Franklin D. Roosevelt, Harry S. Truman and Richard Nixon all stopped at Union Station at some point.

[5] The station was demolished in the middle of June, 1960, with a crowd of approximately 1,000 observing the event.

[6][2] In subsequent years, the adjacent Railway Express Agency building served as the passenger station, and was later the site of the African American Culture Center at Indiana State University.

Passenger service of the Chicago & Eastern Illinois Railroad was withdrawn in 1968, and Penn Central ended service on February 28, 1969 after the remaining passenger trains were moved to the ex-New York Central Railroad line.