[1] Armstrong has worked in the field of neuro-oncology since 1992, and has held faculty positions at Emory University, University of Texas MD Anderson Cancer Center, and the UTHealth Jane and Robert Cizik School of Nursing, where she held the school's Dunn Distinguished Professorship in Oncology Nursing.

She has published 100 manuscripts in peer-reviewed journals and over 15 book chapters on the care of patients with central nervous system tumors in addition to presenting on a regional, national and international level.

[1] Armstrong's program of research focuses on three interlocking areas of research: development of measures and approaches to accurately assess symptom burden and the impact of the disease and therapy on patient outcomes; exploration of the clinical and genomic predictors of risk of symptoms and toxicity; and exploration of the underlying pathophysiology with the overarching goal of developing approaches to care and symptom management that impact outcomes.

These efforts have included the development, psychometric evaluation and assessment of the utility of instruments, and use of patient reported outcomes in multicenter clinical trials.

In addition, Armstrong has led multi-disciplinary teams who are evaluating both clinical and genomic predictors of toxicity and biologic underpinnings of critical symptoms with the goal to improve symptom management and patient outcomes.