Testosterone cypionate, sold under the brand name Depo-Testosterone among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men,[2][3][4] including hormone therapy for transgender men.

[12][13] Testosterone can either directly exert effects on target tissues or be metabolized by 5α-reductase into DHT or aromatized to estradiol (E2).

[17] It is currently FDA approved for the treatment of primary or hypogonadotropic hypogonadism (either congenital or acquired).

[12][13] Testosterone can either directly exert effects on target tissues or be metabolized by 5α-reductase into dihydrotestosterone (DHT) or aromatized to estradiol (E2).

[23][24] Testosterone cypionate was first synthesized in 1951[25] and was introduced for medical use in the United States the same year under the brand name Depo-Testosterone.

[15][16] Testosterone cypionate is the generic name of the drug and its USPTooltip United States Pharmacopeia.

[4][24] It is not widely available outside of the United States, though it has been marketed in Canada, Australia, Spain, Brazil, and South Africa.