[2] Tetrachlorvinphos was initially registered for use in the United States in 1966 by the U.S. Department of Agriculture.

Tetrachlorvinphos was originally registered for use on various food crops, livestock, pet animals, and in or around buildings.

[4] In 2014, the Natural Resources Defense Council (NRDC) filed a lawsuit against the United States Environmental Protection Agency (EPA) seeking EPA to respond to NRDC's 2009 petition to ban tetrachlorvinphos in common pet flea treatment products.

[5][6] Symptoms of exposure to this material include increased perspiration, nausea, lachrymation, salivation, blurred vision, diarrhea, pulmonary edema, respiratory embarrassment and convulsions.

Tetrachlorvinphos is slowly hydrolyzed in neutral and aqueous acidic media.