[3] TEPP is an insecticide to aphids, mites, spiders, mealybugs, leafhoppers, lygus bugs, thrips, leafminers, and many other pests.

[6] Their synthesis made use of ethyl iodide and silver salts to form esters in combination with pyrophosphate.

It reacts with the serine hydroxyl group at the active site, preventing this enzyme from acting on its normal substrate, the neurotransmitter acetyl choline.

[citation needed] TEPP is highly toxic for all warm-blooded animals, including humans.

In a study with frogs, acute exposure caused a depression in the amount of erythrocytes in the blood.

A fellow student Philippe de Clermont is often incorrectly credited as the discoverer of TEPP despite his recognition of the Moschnin primacy in two publications.

In the meantime, organophosphorus chemistry has really started developing with the help of A. W. von Hofmann, Carl Arnold August Michaelis and Aleksandr Arbuzov.

Willy Lange and Gerda von Krueger were the first to report such effects, about which the following statement was published in their article (in German):[20] "Interestingly, we report the strong effect of monofluorophosphate phosphoric acid alkyl esters on the human organism.

Then comes decreased awareness, opacities, and dazzling phenomena causing painful sensitivity of the eye to light.

They are apparently not caused by acidic decomposition products of the ester, but they are probably due to the Dialkyl monofluorophosphates themselves.

[6] Schrader referred to the studies by Eberhard Gross, who was the first to recognize the mechanism of action for TEPP in 1939.