The highway travels east on Hurst Blvd, gradually turning to the northeast.

The road continued eastward on present day US 67 into Fort Stockton, then followed present-day I-10 through Ozona and Sonora.

From there, it headed northeast on US 377 through Brownwood, Comanche, and Granbury toward its terminus in Fort Worth.

In late July 1917, the segment from New Mexico to Lobo (still a proposed route) was assigned to the ambitious SH 12 roadway.

The road was extended, however, through Fort Worth to Denton, replacing SH 40A.

[4] On September 14, 1926, SH 10 was to be extended northeast to Sherman and southwest to Del Rio, with the designation not taken over until January 1, 1928.

[5] On February 20, 1928, the extension to Del Rio was modified to end 2 miles northeast of London.