SH 326 was designated on February 13, 1940 to serve as a route between Sour Lake and Kountze.

[1] SH 326 begins in East Texas at a junction with US 90 and FM 365 in Nome.

It heads north from this junction to an intersection with SH 105 in Sour Lake.

Heading north, the highway continues to a junction with FM 770.

The highway intersects FM 1293 as it enters the Kountze city limits.