State Highway 65 (SH 65) is a Texas state route that runs for 15.495 miles (24.937 km) within Chambers County, from near Anahuac to Stowell.

This route was designated on December 30, 1961, replacing a portion of SH 73 identified as SH 73-T. SH 65 was originally designated on August 21, 1923 along a route from Mt.

Pleasant to Gladewater, replacing part of SH 11.

[2] On September 26, 1939, this route was cancelled as it was part of U.S. Highway 271, which it was cosigned with since 1935.

The entire route is in Chambers County.