(Rusk, Smith, and Van Zandt Counties) SH 64 was originally designated on August 21, 1923 to replace SH 15A from Wills Point to Carthage.

[2] On November 19, 1923, it was extended east to the Louisiana state line.

[3] On September 26, 1939, the portion east of Henderson was already part of U.S. Highway 79, which it was cosigned with since 1935.

[5][6] The two business routes are briefly concurrent through downtown Henderson.

On December 19, 1955, the section from US 79 & FM 840 to US 79 was removed from the state highway system.