8.115 miles (13.060 km) in length, the route is a major arterial in the city, providing access to Brackenridge Park, the San Antonio Zoo, and the University of the Incarnate Word.

[2] It heads northeast along Broadway through Midtown San Antonio, and through the cities of Alamo Heights and Terrell Hills.

[5] On August 1, 1962, when US 81 was rerouted onto the freeway to the east, the old segment was designated as Loop 368, but signed as Business U.S. 81.

[1][9] However, on January 27, 2022, TxDOT announced that it would retain jurisdiction over that portion of Loop 368, noting that the city did not provide the required acceptance letter for the project.

Nirenberg accused the state DoT of "1950s thinking" and having a "religious fascination" with highway expansion.