The loop is a significant thoroughfare around the city, as it is the main connection to Valley International Airport.

The loop begins to curve to the south at this intersection as it passes to the southwest of Valley International Airport.

Heading south through the east side of Harlingen, the loop intersects Spur 206 and FM 106 at Harrison Avenue.

[2] Loop 499 was given a temporary designation on April 29, 1971 until construction began on the highway.

On April 31, 1973, it was officially added to the State Highway System as a route from US 77 to Loop 448.