Texas brown tarantulas can grow to leg spans in excess of 10 cm (4 in),[3] and weigh more than 85 g (3 oz) as adults.

Additionally, A. hentzi and most other tarantulas found in the Americas have small, coarse, brown or black urticating hairs on their abdomens that they kick in the direction of whatever they may feel threatens them.

[10] Due to the large size of their fangs, the puncture wound from a bite can also be painful and lead to secondary infection if not properly treated.

[11][2][12][13] A. hentzi is a terrestrial species commonly found in grasslands, burrowed underground, or using logs, stones, or other small animals' abandoned dens as their homes and feeding grounds.

[14] Texas brown tarantulas use their spinnerets to line the entrance of their shelters with webbing to detect passing prey.