Thackerville is situated near the intersection of U.S. Highway 77 and State Highway 153, five miles north of the Texas state line and ten miles south of Marietta in south central Love County.

[4][5] Interstate 35 passes through town, putting Thackerville on the main route between Oklahoma City and Dallas/Ft.

[6] According to the United States Census Bureau, the town has a total area of 2.1 square miles (5.4 km2), all land.

[5] It is believed that he was headed for the Amarillo, Texas area, but he camped one night at Wolf Hollow Creek in Indian Territory and remained there until his death a few years later.

After Thacker's death in 1887, the community relocated from its original site near where Wolf Creek enters the Red River, to its present location.

The main reason behind the move was to be closer to the Atchison, Topeka, and Santa Fe Railway.

Thackerville had a dirt main street with board walks that connected store porches.

On July 5, 1899, Thackerville was officially incorporated into Indian Territory by Judge Hosea Townsend.

[7] At the time of its founding, Thackerville was located in Pickens County, Chickasaw Nation.